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Pathways Recommended:	Protein Tyrosine Kinase/RTK

Results for "

Dual specificity tyrosine regulated kinase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DYRK (8) 5-HT Receptor (1) CDK (1) Haspin Kinase (2)
By Research Areas:	Cancer (6) Metabolic Disease (1) Neurological Disease (3)

9

Inhibitors & Agonists

2

Natural
Products

7

Recombinant Proteins

Targets Recommended: DYRK SGK Ferroportin ERK Btk Syk Pyk2 BRK FAK FLT3 Anaplastic lymphoma kinase (ALK)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

LDN-192960 2 Publications Verification	Haspin Kinase DYRK	Cancer
LDN-192960 is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC₅₀s of 10 nM and 48 nM, respectively .

LDN-192960 hydrochloride 2 Publications Verification	Haspin Kinase DYRK	Cancer
LDN-192960 hydrochloride is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC₅₀s of 10 nM and 48 nM, respectively .

Harmine Maximum Cited Publications 17 Publications Verification Telepathine	DYRK 5-HT Receptor	Neurological Disease Cancer
Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT_2A serotonin receptor, with an K_i of 397 nM .

HY-N12840

Logmalicid B

Others Metabolic Disease

Logmalicid B is an iridoid glycoside compound that can be isolated from Cornus officinalis and can be used in diabetes research .

DYRKs-IN-1	DYRK	Cancer
DYRKs-IN-1 is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC₅₀s of 5 nM and 8 nM for DYRK1A and DYRK1B, respectively. DYRKs-IN-1 has antitumor activity .

DYRKs-IN-1 hydrochloride	DYRK	Cancer
DYRKs-IN-1 hydrochloride is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC₅₀s of 5 nM and 8 nM for DYRK1A and DYRK1B, respectively. DYRKs-IN-1 hydrochloride has antitumor activity .

ID-8 4 Publications Verification	DYRK	Cancer
ID-8 is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase (DYRK). ID-8 sustains embryonic stem cell (ESC) self-renewal and pluripotency. ID-8 enhances Wnt-mediated hESC survival and proliferation via inhibition of DYRKs .

Dyrk1A-IN-3	DYRK	Neurological Disease
Dyrk1A-IN-3 (Compound 8b), a highly selective dual-specificity tyrosine-regulated kinase 1A (DYRK1A) inhibitor, maintains high levels of DYRK1A binding affinity (IC₅₀=76 nM). Dyrk1A-IN-3 can be used for the research of neurodegenerative disorders such as Alzheimer’s Disease, Huntington’s Disease, and Parkinson’s Disease .

Leucettine L41	CDK DYRK	Neurological Disease
Leucettine L41 is a potent inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), DYRK2, CDC-like kinase 1 (CLK1), and CLK3 (IC₅₀s = 0.04, 0.035, 0.015, and 4.5 µM, respectively) . Leucettine L41 prevents lipid peroxidation and the accumulation of reactive oxygen species (ROS) induced by Aβ_25-35 in the hippocampus in a mouse model of Alzheimer’s disease-like toxicity. Leucettine L41 also prevents memory deficits induced by Aβ_25-35 in the same model .

Species:	Human (7)
Tag:	His (3) Tag Free (1) GST (4) Flag (1)
Source:	Sf9 insect cells (4) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

	DYRK2 Protein, Human (GST) DYRK2; Dual specificity tyrosine-phosphorylation-regulated kinase 2	Human	E. coli
	DYRK2 is a multifunctional serine/threonine protein kinase that complexly controls multiple cellular processes, including the mitotic cell cycle, cell proliferation, apoptosis, cytoskeletal organization, and neurite outgrowth. DYRK2 operates downstream of ATM to phosphorylate p53/TP53 at the “Ser-46” site, leading to DNA damage-induced apoptosis. DYRK2 Protein, Human (GST) is the recombinant human-derived DYRK2 protein, expressed by E. coli , with N-GST labeled tag. The total length of DYRK2 Protein, Human (GST) is 600 a.a., .

	DYRK4 Protein, Human (Sf9, GST) DYRK4; Dual specificity tyrosine-phosphorylation-regulated kinase 4	Human	Sf9 insect cells
	The DYRK4 protein may play a non-essential role in spermatogenesis, suggesting involvement in sperm cell development. Although specific functions and molecular mechanisms are unknown, its association with spermatogenesis suggests that it plays a role in complex pathways controlling male germ cell maturation. DYRK4 Protein, Human (Sf9, GST) is the recombinant human-derived DYRK4 protein, expressed by Sf9 insect cells , with GST tagged.

	DYRK1A Protein, Human DYRK1A; Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual specificity YAK1-related kinase; HP86; Protein kinase minibrain homolog; MNBH; hMNB	Human	E. coli
	DYRK1A protein has dual serine/threonine and tyrosine kinase activities. DYRK1A Protein, Human is the recombinant human-derived DYRK1A protein, expressed by E. coli , with tag free. The total length of DYRK1A Protein, Human is 359 a.a., .

	DYRK4 Protein, Human (Sf9, His, FLAG) DYRK4; Dual specificity tyrosine-phosphorylation-regulated kinase 4	Human	Sf9 insect cells
	The DYRK4 protein may play a non-essential role in spermatogenesis, suggesting involvement in sperm cell development. Although specific functions and molecular mechanisms are unknown, its association with spermatogenesis suggests that it plays a role in complex pathways controlling male germ cell maturation. DYRK4 Protein, Human (Sf9, His, FLAG) is the recombinant human-derived DYRK4 protein, expressed by Sf9 insect cells , with N-Flag, N-8*His labeled tag. The total length of DYRK4 Protein, Human (Sf9, His, FLAG) is 520 a.a., .

	DYRK1A Protein, Human (His) DYRK1A; Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual specificity YAK1-related kinase; HP86; Protein kinase minibrain homolog; MNBH; hMNB	Human	E. coli
	DYRK1A protein has dual serine/threonine and tyrosine kinase activities. DYRK1A Protein, Human (His) is the recombinant human-derived DYRK1A protein, expressed by E. coli , with N-6*His labeled tag. The total length of DYRK1A Protein, Human (His) is 359 a.a., .

	DYRK3 Protein, Human (sf9, His-GST) Dual specificity tyrosine-phosphorylation-regulated kinase 3; REDK; DYRK3	Human	Sf9 insect cells
	DYRK3 is a dual-specificity protein kinase that dissociates membraneless organelles such as stress granules and nuclear speckles in mitosis. DYRK3 Protein, Human (sf9, His-GST) is the recombinant human-derived DYRK3 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of DYRK3 Protein, Human (sf9, His-GST) is 588 a.a., with molecular weight of ~80 KDa.

	DYRK1B Protein, Human (Sf9, GST) DYRK1B; Dual specificity tyrosine-phosphorylation-regulated kinase 1B; Minibrain-related kinase; Mirk protein kinase	Human	Sf9 insect cells
	DYRK1B protein has dual serine/threonine and tyrosine kinase activities. DYRK1B Protein, Human (Sf9, GST) is the recombinant human-derived DYRK1B protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of DYRK1B Protein, Human (Sf9, GST) is 628 a.a., .

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